PUBLICATION

Four most representative publications
1. Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, …..,Howson JMM, Danesh J, McCarthy MI, Cowan CA, Abecasis G, Deloukas P, Musunuru K, Willer CJ, Kathiresan S. Exome-wide association study of plasma lipids in >300,000 individualsNature Genetics 49(12):1758-1766.
2. Zhan X, Hu Y, Li B, Abecasis GR & Liu DJ RVTESTS: An Efficient and Comprehensive Tool for Rare Variant Association Analysis Using Sequence DataBioinformatics, 2016, DOI 10.1093/bioinformatics/btw079
3. Liu DJ, Peloso GM, Zhan X, Holmen O, Zawistowski M, Feng S, Nikpay M, Auer PL, Goel A, Zhang H, Peters U, Farrall M, Orho-Melander M, Kooperberg C, McPherson R, Watkins H, Willer CJ, Hveem, K, Melander O, Kathiresan S, Abecasis GR Meta-analysis of gene-level tests of rare variant associationNature Genetics,  46, 200–204 (2014)
4. Liu DJ, Brazel DM, Turcot V, Zhan X, Gong J, Barnes D, ……., Abecasis GR, Vrieze S, Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior  (biorxiv)

Preprints:
1. Zhan X, Chen S, Jiang Y, Liu M, Iacono WG, Hewitt JK, Hokanson JE, Krauter K, Laakso M, Li KW, Lutz SM, McGue M, Pandit A, Zajac GJM, Boehnke M, Abecasis GR, Jiang B. Vrieze SI, Liu DJ, Association Analysis and Meta-Analysis of Multi-allelic Variants for Large Scale Sequence Data, (biorxiv)
2. Liu DJ, Brazel DM, Turcot V, Zhan X, Gong J, Barnes D, Bertelsen S, Chou Y, Erzurumluoglu M, Faul JD, Haessler J, Hammerschlag AR, Hsu C, Kapoor M, Lai D, Le N, Leeuw CAd, Loukola A, Mangino M, Melbourne CA, Pistis G, Qaiser B, Rohde R, Shao Y, Stringham H, Wetherill L, Zhao W, Agrawal A, Bierut L, Chen C, Eaton CB, Goate A, Haiman C, Heath A, Iacono WG, Martin N, Polderman TJ, Reiner A, Rice J, Schlessinger D, Scholte HS, Smith JA, Tardif J, Tindle HA, Leij ARvd, Boehnke M, Chang-Claude J, Cucca F, David SP, Foroud T, Kardia SL, Kooperberg C, Lettre ML, Madden P, McGue M, North K, Posthuma D, Spector T, Stram D, Weir DR, Kaprio J, Abecasis GR, Vrieze S, Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior, (biorxiv)

Selected Publications: 
1. Jiang Y, Chen S, McGuire D, Chen F, Liu M, Iacono WG, Hewitt JK, Hokanson JE, Krauter K, Laakso M, Li KW, Lutz SM, McGue M, McGuire D, Pandit A, Zajac G, Boehnke M, Abecasis GR, Vrieze SI, Zhan X, Jiang B, Liu DJ†Proper Conditional Analysis in the Presence of Missing Data: Application to Large Scale Meta-analysis of Tobacco Use Phenotypes, PLOS Genetics 14(7):e1007452
2. Liu DJ*, Peloso GM*, Yu H*, Butterworth AS*, Wang X*, Mahajan A*, Saleheen D*, Emdin C*, …..,Howson JMM, Danesh J, McCarthy MI, Cowan CA, Abecasis G, Deloukas P, Musunuru K, Willer CJ, Kathiresan S. Exome-wide association study of plasma lipids in >300,000 individualsNature Genetics 2017;49(12):1758-1766.
3. Zhan X, Hu Y, Li B, Abecasis GR & Liu DJ† RVTESTS: An Efficient and Comprehensive Tool for Rare Variant Association Analysis Using Sequence DataBioinformatics, 2016, DOI 10.1093/bioinformatics/btw079
4. Liu DJ†*, Peloso GM*, Zhan X, Holmen O, Zawistowski M, Feng S, Nikpay M, Auer PL, Goel A, Zhang H, Peters U, Farrall M, Orho-Melander M, Kooperberg C, McPherson R, Watkins H, Willer CJ, Hveem, K, Melander O, Kathiresan S, Abecasis GR Meta-analysis of gene-level tests of rare variant associationNature Genetics,  46, 200–204 (2014)
5. Zhan X*, Liu DJ*  SEQMINER: An R-package to Facilitate the Functional Interpretation of Sequence-based AssociationsGenet Epidemiol. 2015 Sep 23. doi: 10.1002/gepi.21918
6. Liu DJ†, Leal SM† A unified method for detecting secondary trait associations with rare variants: application to sequence dataPLOS Genetics 8(11): e1003075 (link)
7. Liu DJ, Leal SM† Estimating genetic effects and quantifying missing heritability explained by identified rare variant associations, Am J Hum Genet 91:585-596 (link) (media coverage) (Highlights in Nature Genetics)
8. Liu DJ†, Leal SM†  SEQCHIP: A powerful method to integrate sequence and genotype data for the detection of rare variant associationsBioinformatics 28(13):1745-1751 (link)
9. Liu DJ, Leal SM† Replication Strategies for Rare Variant Complex Trait Association Studies via Next-Generation SequencingAm J Hum Genet 87:790-801 (link) (media coveage)
10. Liu DJ, Leal SM A novel adaptive method for the analysis of next-generation sequencing data to detect complex trait associations with rare variants due to gene main effects and interactions,PLOS Genetics 6:e1001156 (link) (media coverage)

*Equal contribution first author

†: Corresponding author

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